Rare Disease Day is a global event that serves to raise awareness of over 7,000 identified rare diseases. Although each disease on its own is rare, together they affect approximately 1 in 10 Americans. Since 2015, the Frank H. Netter MD School of Medicine has hosted a Rare Disease Day Symposium, providing an opportunity for patients, family members, clinicians, and researchers to share their stories, research and insight into the development of novel therapeutics. Our mission is to promote interprofessional healthcare, awareness and advocacy for the rare disease community with an event that has also become a powerful learning opportunity for students and professionals highlighting the unique needs of individuals affected by rare disorders. Our audience includes patients/family members, practitioners, researchers and graduate/medical students and allied healthcare professional students. We recognize the unique opportunity to partner with the All of Us (AoU) Research Program to promote the similar mission of AoU.